Severe hyperbilirubinemia may develop in a newborn infant if one or more risk factors are present.
Neonatal risk factors:
(1) male gender (minor risk)
(2) gestational age 35 to 38 weeks (major at 35-36 weeks; minor at 37-38 weeks)
(3) jaundice present within first 24 hours after delivery (major risk)
(4) jaundice visible before discharge from the hospital (minor risk)
(5) a site of hemorrhage undergoing resorption (extensive bruising, cephalohematoma, other; major risk)
(6) inadequate nutrition and/or dehydration associated with exclusive but suboptimal breastfeeding (major risk)
(7) unrecognized hemolysis (ABO or other blood group incompatibility. G6PD deficiency, other; major risk)
(8) macrosomia associated with maternal diabetes (minor risk)
(9) predischarge serum bilirubin elevated (major if above the 95th percentile; minor if 75 to 95th percentile)
Maternal risk factors:
(1) age >= 25 years (minor risk)
Familial risk factors
(1) previous affected sibling (major if phototherapy given; minor with jaundice)
(2) race East Asian (major risk)
where:
• Being of Mediterranean origin may be a risk factor, but this may reflect hemolytic disease.
Purpose: To identify risk factors associated with serious hyperbilirubinemia in a neonate.
Specialty: Pedatrics, Gastroenterology
Objective: risk factors, clinical diagnosis, including family history for genetics, criteria for diagnosis, disease progression
ICD-10: P59,