Colmenero et al identified risk factors which can help identify a patient with brucellosis who is more likely to develop complications. The authors are from Carlos Haya University Hospital in Malaga, Spain.
Parameters:
(1) duration of symptoms in days
(2) erythrocyte sedimentation rate (ESR)
(3) serum alpha-2 globulin concentration in g/L
Parameter |
Finding |
Points |
duration of symptoms |
<= 30 days |
0 |
|
> 30 days |
1 |
ESR |
<= 40 mm per hr |
0 |
|
> 40 mm per hour |
1 |
serum alpha-2 globulin |
<= 7.6 g/L |
0 |
|
> 7.6 g/dL |
3 |
where:
• 7.6 g/L is equivalent to 0.76 g/dL
• The odds ratios were around 2 for duration and ESR. It was approximately 7 for the serum alpha-2 globulin.
• Alpha-2 globulin is an acute phase reactant that is increased in acute or chronic inflammation.
• Complications refer to a focal organ involvement (osteomyelitis, endocarditis, etc). Some types of focal disease are more serious than others.
• Immunodeficiency or immunosuppression might be an additional risk factor.
total risk score =
= SUM(points for the 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
• The higher the score the greater the risk for complications.
Specialty: Infectious Diseases