Risk Factors of Ferrone et al Associated with Survival in a Patient with Resectable Pancreatic Adenocarcinoma

 

Patient selection: resectable pancreatic adenocarcinoma (T1 to T3 and M0)

 

Parameters identified on multivariate analysis:

(1) change in the serum CA19-9 concentration before and after surgery

(2) serum concentration of CA19-9 after surgery

(3) T stage

(4) N stage (presence or absence of lymph node metastases)

Parameter	Finding	Points
change in serum CA19-9	postoperative decrease or no change	0
	postoperative increase	1
postoperative CA19-9 level	<= 200 U/mL (<= 5.4 times ULN)	0
	> 200 U/mL (> 5.4 times ULN)	1
T stage	T1 or T2	0
	T3	1
lymph node metastases	absent (N0)	0
	present (N1)	1

 

where:

• The upper limit of the normal reference range for serum CA19-9 was 37 U/mL.

• The odds ratios for the risk factors ranged from 2.5 to 3.2.

 

number of risk factors associated with increased mortality =

= SUM(points for all 4 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 4

• The higher the score the worse the survival.