Fiorenza et al identified features of chondrosarcoma arising in bone that adversely affect different outcomes. This can help identify a patient who may require more aggressive therapy. The authors are from the Royal Orthopaedic Hospital in Birmingham, England.
Parameters adversely affecting prognosis:
(1) locally recurrent
(2) high grade
(3) extracompartmental spread (this appears to refer to tumors extend into soft tissue)
(4) size, with diameter > 10 cm
(5) excision with positive (inadequate) margins
Outcomes:
(1) local recurrence
(2) metastases
(3) survival
Factors Affecting Local Recurrence |
Hazard Ratio |
95% CI |
p value |
positive margins |
8.0 |
3.0 to 20.9 |
< 0.0001 |
size > 10 cm |
2.0 |
1.0 to 4.0 |
0.04 |
from Table IV, page 97, with p < 0.05
Factors Affecting Metastases |
Hazard Ratio |
95% CI |
p value |
local recurrence |
3.2 |
1.5 to 6.6 |
0.001 |
high grade |
4.4 |
2.2 to 9.0 |
< 0.0001 |
extracompartmental spread |
4.2 |
1.3 to 14.2 |
0.02 |
from Table V, page 97, with p < 0.05
Factors Affecting Survival |
Hazard Ratio |
95% CI |
p value |
local recurrence |
3.4 |
1.6 to 7.1 |
0.002 |
high grade |
4.7 |
2.1 to 10.4 |
0.0001 |
extracompartmental spread |
5.1 |
1.5 to 29.2 |
0.02 |
from Table III, page 97, with p < 0.05
where:
• The risk factors for metastases and survival are the same, and the hazard ratios are similar.
Specialty: Hematology Oncology, Surgery, general, Surgery, orthopedic