Description

Fiorenza et al identified features of chondrosarcoma arising in bone that adversely affect different outcomes. This can help identify a patient who may require more aggressive therapy. The authors are from the Royal Orthopaedic Hospital in Birmingham, England.


 

Parameters adversely affecting prognosis:

(1) locally recurrent

(2) high grade

(3) extracompartmental spread (this appears to refer to tumors extend into soft tissue)

(4) size, with diameter > 10 cm

(5) excision with positive (inadequate) margins

 

Outcomes:

(1) local recurrence

(2) metastases

(3) survival

Factors Affecting Local Recurrence

Hazard Ratio

95% CI

p value

positive margins

8.0

3.0 to 20.9

< 0.0001

size > 10 cm

2.0

1.0 to 4.0

0.04

from Table IV, page 97, with p < 0.05

 

Factors Affecting Metastases

Hazard Ratio

95% CI

p value

local recurrence

3.2

1.5 to 6.6

0.001

high grade

4.4

2.2 to 9.0

< 0.0001

extracompartmental spread

4.2

1.3 to 14.2

0.02

from Table V, page 97, with p < 0.05

 

Factors Affecting Survival

Hazard Ratio

95% CI

p value

local recurrence

3.4

1.6 to 7.1

0.002

high grade

4.7

2.1 to 10.4

0.0001

extracompartmental spread

5.1

1.5 to 29.2

0.02

from Table III, page 97, with p < 0.05

 

where:

• The risk factors for metastases and survival are the same, and the hazard ratios are similar.

 


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