He et al reported risk factors for progression of interstitial lung disease (ILD) in a patient with Sjogren's Syndrome. The authors are from Zhengzhou University.
Patient selection: Sjogren's syndrome-related interstitial lung disease
Parameters:
(1) type of onset
(2) baseline serum LDH in U/L, from 0 to 500
(3) baseline FVC as percent of predicted, from 40 to 130
points for serum LDH =
= 0.1704 * (serum LDH)
points for FVC =
= 144.44 - (1.11 * (FVC))
|
Onset
|
Points
|
|
sicca
|
0
|
|
non-sicca
|
35.3
|
score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 220.5
value of X =
= (0.04177 * (score)) - 5.699
probability of ILD progression =
= 1 / (1 + EXP((-1) * X))
Performance:
• The area under the ROC curve is 0.80.
Additional factors associated with progressive disease:
(1) male sex
(2) reticular pattern on high-resolution CT of the lung (HRCT)
