Ihaddadene et al identified risk factors for an occult malignancy in a patient with an unprovoked venous thromboembolism (VTE). These can help to identify a patient who may benefit from more aggressive management. The authors are from multiple institutions in Canada.
Patient selection: first unprovoked venous thromboembolism (VTE) and no known malignancy
Outcome: eventual diagnosis of malignancy (within 5 years)
Risk factors:
(1) age >= 60 years (hazard ratio 3.1)
(2) current smoker (hazard ratio 2.8)
(3) history of a previous provoked VTE (hazard ratio 3.2)
Age
Smoker
Previous VTE
2 Year
5 Year
< 60
no
no
0.2
1.8
< 60
no
yes
0.7
5.7
< 60
yes
no
0.6
5.0
< 60
yes
yes
1.8
15.2
>= 60
no
no
0.6
5.6
>= 60
no
yes
2.0
16.8
>= 60
yes
no
1.8
14.8
>= 60
yes
yes
5.5
40.2
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