Risk Factors of Lucarelli et al Affecting Outcome for a Patient with Thalassemia Who Has Undergone Bone Marrow Transplantation

 

Patient population: homozygous beta-thalassemia

 

Factors associated with a poor outcome:

(1) portal fibrosis

(2) one or both of the following:

(2a) hepatomegaly (> 2 cm, presumably below the right costal margin)

(2b) inadequate chelation therapy

 

Number of Factors Present	3 Year Survival
0	94%
1	80%
2	61%

 

 

Additional factors associated with a better outcome:

(1) age < 16 years of age

(2) HLA-identical donor

 

Limitations:

• Survival following bone marrow transplantation probably has improved since the paper was written.