Schinderwolf et al identified risk factors for delayed hypersensitivity type skin lesions associated with heparin therapy. The authors are from Wolfgang Goethe University, DRK-Blooddonorservice (Dessau) and the University of Lubeck.
Parameters:
(1) gender
(2) body mass index (BMI)
(3) duration of heparin therapy
Parameter
Finding
Points
gender
male
0
female
1
body mass index
<= 25 kg per square meter
0
> 25 kg per square meter
1
duration of heparin therapy
<= 9 days
0
> 9 days
1
total number of risk factors =
= SUM(points for all 3 parameters)
Interpretation:
• minimum number of risk factors: 0
• maximum number of risk factors: 3
• The risk of a delayed hypersensitivity type skin reaction increases with the number of risk factors (individual odds ratios range from 3 to 6).
Additional factors:
(1) age > 60 years
(2) history of previous exposure to heparin
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