Risk Factors of Shaib et al for Cholangiocarcinoma

Description

Shaib et al identified risk factors for cholangiocarcinoma (CC). These can help identify who should be targeted for preventive measures. The authors are from the Houston Veterans Affairs Medical Center, Baylor College of Medicine, M.D. Anderson Cancer Center and the University of New Mexico.

Risk Factor	Intrahepatic CC	Extrahepatic CC
chronic HCV infection	Yes	Yes
chronic HBV infection	Yes	Yes
cirrhosis	Yes
heavy alcohol use	Yes	Yes
age >= 50 years		Yes

based on odds ratios in Table 2, page 1019

where:

• The patterns of HBV serology reported in Table 2 (page 1019) are consistent with chronic active hepatitis B.

• The definition of heavy alcohol use was > 80 grams per day. The typical alcoholic drink contains 10-15 grams of alcohol, so this is 6 - 8 drinks per day.

• Mild to moderate drinking was associated with a reduced risk for extrahepatic cholangiocarcinoma.

NOTE: The presence of trematodes (Clonorchis and Opisthorchis species) in the bile ducts is a risk factor for cholangiocarcinoma in developing countries.

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Specialty

ICD-10