Risk for Malignant Hyperthermia in a Patient with Exercise-Induced Rhabdomyolysis

Patient selection: exercise-induced rhabdomyolysis

Findings which may suggest an underlying predisposition to malignant hyperthermia:

(1) family members with a history of malignant hyperthermia

(2) previous episodes of exercise-induced rhabdomyolysis and/or heat stroke

(3) severity of rhabdomyolysis episode excessive for the triggering episode

A patient who is suspected of having malignant hyperthermia should be tested for mutations in the ryanodine receptor gene (RYR1).