Patient selection: acute pulmonary embolism (PE)
Outcomes: major in-hospital complications and death
Parameters:
(1) echocardiography for right ventricular dysfunction
(2) serum N-terminal pro-brain natriuretic peptide (NT pro-BNP, Elecsys 2010 analyzer, Roche Diagnostics)
(3) serum troponin T (Elecsys 2010 analyzer, Roche Diagnostics)
Echocardiography evidence of right ventricular dysfunction - both of the following:
(1) dilatation of the right ventricle (end-diastolic diameter > 30 mm from parasternal view; right ventricle appearing larger than the left ventricle on subcostal or apical view)
(2) right atrial hypertension (absence of inspiratory collapse of the inferior vena cava)
Model 1:
(1) NT proBNP in pg/mL
(2) right ventricular dysfunction on echocardiography
|
NT proBNP
|
Echocardiography
|
Odds Ratio of Compli-cated In-Hospital Course
|
|
< 1,000 pg/mL
|
NA
|
1.0
|
|
>= 1,000 pg/mL
|
negative
|
3.3
|
|
NA
|
positive
|
12.2
|
Model 2:
(1) troponin T (reference range < 0.04 ng/mL)
(2) right ventricular dysfunction on echocardiography
|
Troponin-T
|
Echocardiography
|
Odds Ratio of Compli-cated In-Hospital Course
|
|
< 0.04 ng/mL
|
negative
|
1.0
|
|
>= 0.04 ng/mL
|
negative
|
3.7
|
|
< 0.04 ng/mL
|
positive
|
5.6
|
|
>= 0.04 ng/mL
|
positive
|
10.0
|
