Reitz et al developed a score for identifying a patient at increased risk for late-onset Alzheimer disease. The authors are from Columbia University in New York City.
Patient selection: age >= 65 years; race White, Black or Hispanic; free of dementia at baseline
Parameters:
(1) gender
(2) age in years
(3) diabetes mellitus
(4) current smoking
(5) low serum HDL-C
(6) high waist-to-hip ratio (WHR)
(7) years of education
(8) race/ethnicity
(9) APOE epsilon-4 allele
|
Parameter |
Finding |
Points |
|---|---|---|
|
gender |
male |
0 |
|
|
female |
1 |
|
age |
65 to 70 |
0 |
|
|
71 to 75 |
6 |
|
|
76 to 80 |
12 |
|
|
81 to 85 |
14 |
|
|
>= 86 |
25 |
|
diabetes |
no |
0 |
|
|
yes |
2 |
|
current smoking |
no |
0 |
|
|
yes |
7 |
|
low HDL-C |
no |
0 |
|
|
yes |
4 |
|
high waist-to-hip ratio |
no |
0 |
|
|
yes |
9 |
|
years of education |
0 to 6 |
10 |
|
|
7 to 9 |
8 |
|
|
>= 10 |
0 |
|
race |
White |
0 |
|
|
Black |
5 |
|
|
Hispanic |
7 |
|
APOE epsilon-4 allele |
0 |
0 |
|
|
>= 1 |
5 |
total score for probable LOAD =
= SUM(points for all 9 parameters)
Interpretation:
• minimum score: 0
• maximum score: 70
• The higher the score the more likely the patient has late-onset Alzheimer's disease.
|
Total Score |
Risk for LOAD |
|
0 to 14 |
1 |
|
15 to 22 |
3.6 times |
|
23 to 28 |
12.6 times |
|
>= 29 |
20.5 times |
Purpose: To evaluate a patient for the risk of late-onset Alzheimer disease use the LOAD score of Reitz et al.
Specialty: Neurology
Objective: severity, prognosis, stage
ICD-10: F00,
