The Radiation Therapy Oncology Group (RTOG) and the European Organization for Research on the Treatment of Cancer (EORTC) provide criteria for assessing the complications of radiation therapy affecting the liver.
Guidelines:
(1) Change in affected parameter is ascribed to radiation therapy and not underlying or concurrent disease.
(2) Considered acute if occurs from day 1 to 90; after day 90 considered late complication.
Late Complications
Grade 0: no change
Grade 5: death due to hepatic injury
Hepatic Injury
Grade 1
Grade 2
Grade 3
Grade 4
symptoms
mild lassitude, nausea and/or dyspepsia
moderate symptoms
disabling symptoms
NA
liver function tests
slightly elevated
moderately elevated
markedly elevated
NA
serum albumin
normal
normal
decreased
NA
other
NA
NA
ascites, edema
necrosis
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