RTOG/EORTC Criteria for Ocular Complications to Irradiation

Description

The Radiation Therapy Oncology Group (RTOG) and the European Organization for Research on the Treatment of Cancer (EORTC) provide criteria for assessing the complications of radiation therapy affecting the eyes.

Guidelines:

(1) Change in affected parameter is ascribed to radiation therapy and not underlying or concurrent disease.

(2) Considered acute if occurs from day 1 to 90; after day 90 considered late complication.

Acute Complications

Grade 0: none (no change from baseline)

Injury	Grade 1	Grade 2	Grade 3	Grade 4
conjunctivitis and/or keratitis	mild with or without scleral injection	moderate with or without keratitis	severe keratitis with corneal ulceration	NA
inflammation	NA	iritis with photophobia	panophthal-mitis	NA
visual acuity	NA	NA	objective decrease in visual acuity or in visual fields	loss of vision (unilateral or bilateral)
other	increased tearing	dry eye requiring artificial tears	acute glaucoma	NA

where:

• Moderate or severe keratitis may require therapy (steroids and/or antibiotics).

Note: Death to acute radiation effects (Grade 5) would not be expected with radiation to the eyes.

Late Complications

Grade 0: no change

Injury	Grade 1	Grade 2	Grade 3	Grade 4
cataract	asymptomatic	symptomatic	NA	NA
corneal ulceration	minor	moderate	NA	NA
keratitis	minor	moderate	severe	NA
glaucoma	NA	mild	severe	NA
retinopathy	NA	minor	severe	NA
other	NA	NA	retinal detachment	panophthal-mitis with blindness

Note: Death to late radiation effects (Grade 5) would not be expected with radiation to the eyes.

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Description

Specialty

ICD-10