Andrews et al reported screening criteria for an adult with lymphocytosis that can help to identify a patient who may have an abnormal immunophenotype on flow cytometry. The authors are from Madigan Army Medical Center in Tacoma, Washington.
Patient selection: adult with lymphocytosis
Parameters:
(1) age in years
(2) absolute lymphocyte count
absolute lymphocyte count in 10^9/L =
= (white blood cell count in 10^9/L) * (percent lymphocytes) / 100
Age in Years
Absolute Lymphocyte Count
Increased Risk Abnormal Immunophenotype
> 67 years
>= 4 * 10^9/L
Yes
< 4 * 10^9/L
No
50 to 67 years
> 6.7 * 10^9/L
<= 6.7 *10^9/L
Performance:
• The area under the ROC curve is 0.8 (Figure 1).
• The sensitivity was 95% and specificity 76% (Table IV).
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Specialty: Hematology Oncology, Clinical Laboratory, Infectious Diseases
