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Selection of Antibiotics to Treat Sepsis Caused By Vibrio Vulnificus

Description

Sepsis caused by Vibrio vulnificus can be fatal for an immunocompromised patient and must be treated appropriately. Liu et al studied outcomes in patients with Vibrio vulinifus sepsis treated with different antibiotic regimens. The authors are from Chang Gung University, National Cheng Kung University, Kaohsiung Veterans General Hospital and National Taiwan University Hospital.


 

Patient selection: septicemia due to Vibrio vulnificus

 

A key clinical determinant is the presence or absence of hemorrhagic bullous necrotic cutaneous lesions (HBNCL).

 

Combination regimen if HBNCL are absent - both of the following:

(1) first or second generation cephalosporin

(2) an aminoglycoside

 

Combination regimen if HBNCL are present - both of the following:

(1) third generation cephalosporin (ceftazidime, cefotaxime, ceftriaxone, moxalactam)

(2) a tetracycline (tetracycline, minocycline, doxycycline, oxytetracycline)

 

If the patient cannot tolerate a tetracycline then another antibiotic (aminoglycoside, other) can be chosen but will be less effective.

 


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