Seoul Virus with Hantavirus-Associated with Hemorrhagic Fever with Renal Syndrome (HFRS)

Distribution: world-wide, primarily East Asia

Animal host: brown Norway rat (Rattus norvegicus), other rodents

Transmission: aerosolized urine, fecal droppings or saliva

Many infections may be subclinical or mild.

Clinical findings:

(1) fever

(2) myalgias

(3) renal failure

(4) hypotension

(5) hemorrhage

The mortality rate is about 1-2% of patients with clinical disease.

Laboratory findings:

(1) thrombocytopenia

(2) leukocytosis

(3) elevated liver function tests

(4) hypoxemia

(5) elevated serum creatinine

(6) elevated C-reactive protein (CRP)

Diagnosis can be made by serology or PCR.