Zhou et al predicted hepatic fibrosis in patients with chronic hepatitis B using a score based on laboratory test results. The authors are from Shanghai Jiaotong University in Shanghai.
Patient selection: chronic hepatitis B (HBV)
Parameters:
(1) serum GGT in IU/L
(2) platelet count in 10^9/L
(3) serum albumin in g/L
S index =
= (GGT) * 1000 / ((platelet count) * ((albumin)^2))
Interpretation:
• minimum score: 0
• maximum score: around 3.5
• An index >= 0.5 is associated with significant fibrosis.
Index
Status
< 0.2
absence of fibrosis
< 0.3
absence of cirrhosis
>= 0.6
advanced fibrosis
>= 1.5
cirrhosis
Performance:
• The area under the ROC curve was 0.81 for significant fibrosis and 0.89 for cirrhosis.
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Specialty: Gastroenterology
