Simplified Method of Pawlotsky et al for the Sigma ESR

Description

The erythrocyte sedimentation rate (ESR) is affected by the patient's hemoglobin and hematocrit levels as well as other factors (see previous section). Pawlotsky et al developed the Sigma ESR which involves adjusting the specimen hematocrit and summing readings taken at 4 times during the first hour of sedimentation. Pawlotsky has since developed a simplified version to increase acceptance of the approach.

Specimen collection:

(1) 5.2 mL blood collected in a glass Seditainer tube (10.25 by 120 mm) anticoagulated with lithium heparin.

(2) Blood sample for hemoglobin and hematocrit measurement.

Parameters:

(1) measurement of sedimentation distances at 30 and 60 minutes

(2) hematocrit as a decimal fraction from 0 to 1

(3) hemoglobin in g/L

summed distance in mm =

= (distance at 30 minutes) + (distance at 60 minutes)

simplified sigma ESR =

= ((-0.005 * ((summed distance)^2)) + (2.542 * (summed distance)) + (802.526 * (hematocrit)) - (0.92 * (hemoglobin)) - 164.701) / 2

Interpretation:

• The reference range is 17 to 53 mm in the first hour for both genders and all ages.

• The upper limit of the reference range is affected by the serum total cholesterol level.

Serum Cholesterol	Upper Limit of the Reference Range
<= 5.0 mmol/L	50 mm/h
5.01 - 6.00	54 mm/h
6.01 - 6.50	59 mm/h

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Description

Specialty

ICD-10