Sangro et al identified risk factors for sinusoidal obstruction syndrome (veno-occlusive disease) occurring in a patient undergoing radioembolization of a liver tumor. The authors are from the University of Pamplona in Spain.
Term used: REILD = radioembolization induced liver disease
Patient selection: hepatocellular carcinoma or hepatic metastases from colon cancer
Radioembolization therapy was performed with yttrium 90 labeled microspheres.
Onset after treatment: 4-8 weeks
Clinical features:
(1) jaundice
(2) ascites
(3) veno-occlusive disease in severe cases
Some patients progressed to liver failure, which could be fatal.
Risk factors:
(1) age < 55 years of age
(2) high dose of radioactivity to the targeted liver, at > 0.8 GBq/L
(3) more than 1 hepatic lobe treated (stated in the abstract)
(4) previous chemotherapy, recent or high dose
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