British Isles Lupus Assessment Group (BILAG) developed an index for evaluating disease activity in patients with systemic lupus erythematosus (SLE). The index is based on several findings, each of which is categorized. The authors are from multiple universities in Great Britain.
Parameters:
(1) white blood cell count per µL
(2) platelet count per µL
(3) hemoglobin
(4) lymphocyte count
(5) hemolytic anemia
(6) circulating lupus anticoagulant
|
Parameter |
Severe |
Moderate |
Mild |
|
WBC count |
< 1,000 per µL |
1,000 - 2,499 |
2,500 - 3,999 |
|
platelet count |
< 25,000 per µL |
25,000 to 99,999 |
100,000 to 149,999 |
|
hemoglobin |
< 8 g/dL |
8 to 10.9 |
NA |
|
absolute lymphocyte count |
NA |
NA |
< 1,500 per µL |
|
hemolytical anemia |
NA |
active hemolysis |
positive DAT without active hemolysis |
|
circulating lupus anticoagulant |
NA |
NA |
present |
where:
• Active hemolysis = anemia + elevated serum bilirubin + positive DAT +/- reticulocytosis.
• DAT = direct antiglobulin (Coombs) test
|
Severe |
Moderate |
Mild |
Status |
Category |
|
any |
NA |
NA |
current |
A |
|
none |
any |
NA |
current |
B |
|
none |
none |
any |
current |
C |
|
none |
none |
none |
previous |
D |
|
none |
none |
none |
never |
E |
Purpose: To categorize hematological findings in a patient with systemic lupus erythematosus (SLE) being evaluated with the BILAG index.
Specialty: Immunology/Rheumatology
Objective: severity, prognosis, stage, differential diagnosis and mimics, red flags, disease progression, prevention
ICD-10: I50.1, M32,
