Description

Bejar et al identified somatic mutations associated with a poor outcome for patients with the myelodysplastic syndrome undergoing hematopoietic stem cell transplantation (HSCT). These can help to identify a patient who may or may not benefit from the procedure. The authors are from the University of California at San Diego, Dana Farber Cancer Institute, Brigham and Women's Hospital and Broad Institute (Cambridge).


 

Patient selection: myelodysplastic syndrome (MDS)

 

Outcome: overall survival after HSCT

 

Mutation analysis:

(1) TP53

(2) TET2

(3) DNMT3A

Mutations

Negative For

4 Year Overall Survival

TP53

 

0%

TET2

TP53

30%

DNMT3A

TP53, TET2

33%

none

TP53, TET2, DNMT3A

60%

 

A patient with mutated TP53 and complex karyotype had the worse survival (0% survival at 27 months).

 


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