Sripongpun et al reported the Steatosis-associated Fibrosis Estimator (SAFE) score as a measure of hepatic fibrosis in a patient with non-alcoholic steatohepatitis (NAFLD). The authors are from Stanford University and Prince of Songkla University in Thailand.
Patient selection: non-alcoholic fatty liver disease (NAFLD) in primary care
Parameters:
(1) age in years
(2) body mass index (BMI) in kg per square meter
(3) serum AST in U/L
(4) serum ALT in U/L
(5) serum glubulin in g/L
(6) platelet count in 10^9/L
(7) diabetes
Parameter
Finding
Points
age in years
2.97 * (age)
BMI
5.99 * (BMI)
serum AST
154.85 * LN(AST)
serum ALT
-58.23 * LN(ALT)
serum globulin
195.48 * LN(globulin)
platelet count
-141.61 * LN(platelet)
diabetes
no
0
yes
62.85
SAFE score =
= SUM(points for all of the parameters) - 75
Interpretation:
• Scores usually range from -200 to 200
• The higher the score, the greater the risk of liver stiffness (>= 8.0 kPa).
Score
Risk Category
Hepatic Fibrosis (van Kleef)
< 0
low
4%
0 to 99.99
intermediate
11%
>= 100
high
28% (40-70% if >= 200)
Performance:
• The area under the ROC curve is 0.73.
To read more or access our algorithms and calculators, please log in or register.