Description

Sripongpun et al reported the Steatosis-associated Fibrosis Estimator (SAFE) score as a measure of hepatic fibrosis in a patient with non-alcoholic steatohepatitis (NAFLD). The authors are from Stanford University and Prince of Songkla University in Thailand.


Patient selection: non-alcoholic fatty liver disease (NAFLD) in primary care

 

Parameters:

(1) age in years

(2) body mass index (BMI) in kg per square meter

(3) serum AST in U/L

(4) serum ALT in U/L

(5) serum glubulin in g/L

(6) platelet count in 10^9/L

(7) diabetes

 

Parameter

Finding

Points

age in years

 

2.97 * (age)

BMI

 

5.99 * (BMI)

serum AST

 

154.85 * LN(AST)

serum ALT

 

-58.23 * LN(ALT)

serum globulin

 

195.48 * LN(globulin)

platelet count

 

-141.61 * LN(platelet)

diabetes

no

0

 

yes

62.85

 

SAFE score =

= SUM(points for all of the parameters) - 75

 

Interpretation:

• Scores usually range from -200 to 200

• The higher the score, the greater the risk of liver stiffness (>= 8.0 kPa).

 

Score

Risk Category

Hepatic Fibrosis (van Kleef)

< 0

low

4%

0 to 99.99

intermediate

11%

>= 100

high

28% (40-70% if >= 200)

 

Performance:

• The area under the ROC curve is 0.73.


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