Palma et al reported the STRIPE algorithm for predicting radiation pneumonitis with lung cancer undergoing chemoradiation. The authors are from multiple institutions in Canada, the United States, Europe, and Korea.
STRIPE = systematic analysis of toxicity after radical irradiation: pneumonitis and esophagitis
Patient selection: lung cancer, with chemoradiation
Parameters:
(1) type of chemotherapy
(2) age in years
(3) mean lung dose in Gy (MLD)
(4) V20 (percentage of lung volume receiving >= 20 Gy)
Chemotherapy
Age in Years
MLD
V20
Risk
carboplatin/paclitaxel
> 65
NA
NA
high
carboplatin/paclitaxel
<= 65
< 10 Gy
NA
low
carboplatin/paclitaxel
<= 65
>= 10 Gy
NA
intermediate
cisplatin/etoposide
NA
NA
< 25%
low
cisplatin/etoposide
NA
NA
>= 25%
intermediate
If V20 was 30 to 39% the fatal mortality rate was 2.9%.
If V20 was >= 40% the fatal pneumonitis rate was 3.5%
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