Jin et al reported the Supra-Blan2t to predict outcome at 3-months after intravenous thrombolysis for acute ischemic stroke. The authors are from Huazhong University of Science and Technology, China Three Gorges University, and affiliated hospitals in China.
Supra-Blan2t is an acronym for sugar, platelet to lymphocyte ratio, age, bilirubin, atrial fibrillation, NIHSS, neutrophil, and troponin.
Patient selection: acute ischemic stroke
Outcome: poor if modified Rankin scale from 3-6 at 3-months
Parameters:
(1) age in years
(2) history of atrial fibrillation
(3) NIHSS score at baseline
(4) blood glucose at baseline in mmol/L
(5) absolute neutrophil count at baseline in 10^9/L
(6) serum direct bilirubin at baseline in µmol/L
(7) serum troponin I at baseline in ng/L
(8) platelet to lymphocyte ratio, presumable at baseline
|
Parameter
|
Finding
|
Points
|
|
age in years
|
<= 70 years
|
0
|
|
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> 70 years
|
1
|
|
history of atrial fibrillation
|
no
|
0
|
|
|
yes
|
1
|
|
NIHSS score
|
0 to 7
|
0
|
|
|
8 to 15
|
2
|
|
|
>= 16
|
3
|
|
blood glucose
|
<= 6 mmol/L
|
0
|
|
|
> 6 mmol/L
|
1
|
|
absolute neutrophil count
|
<= 6 * 10^9/L
|
0
|
|
|
> 6 * 10^9/L
|
2
|
|
serum direct bilirubin
|
<= 5 µmol/L
|
0
|
|
|
> 5 µmol/L
|
1
|
|
troponin I
|
<= 26 ng/L
|
0
|
|
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> 26 ng/L
|
1
|
|
platelet to lymphocyte ratio
|
<= 180
|
0
|
|
|
> 180
|
1
|
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 11
|
Total Score
|
Risk Category
|
Poor Outcome
|
|
0 to 2
|
low
|
9%
|
|
3 to 5
|
medium
|
17%
|
|
6 to 11
|
high
|
59%
|
Performance:
• The area under the ROC curve was 0.82 in the derivation and 0.84 in the validation cohorts.
