Total Activity Score of Cutaneous LE Disease Area and Severity Index (CLASI)

 

Parameters for the activity score:

(1) erythema in 13 anatomical locations

(2) scale or hypertrophy in 13 anatomical locations

(3) lesions on mucous membranes

(4) recent hair loss within the past 30 days

(5) alopecia in 4 scalp quadrants (dividing lines = sagittal midline and coronal at the external acoustic meatus)

 

Anatomical locations:

(1) scalp

(2) ears

(3) nose and malar region

(4) rest of face

(5) V area of chest and neck in front

(6) posterior neck and shoulders

(7) chest

(8) abdomen

(9) back and buttocks

(10) arms

(11) hands

(12) legs

(13) feet

Erythema in Each Location	Points
none	0
pink	1
red	2
dark red or violaceous	3
crusted or hemorrhagic	3

 

subscore for erythema =

= SUM(points for erythema in each anatomic location)

 

Scale or Hypertrophy in Each Location	Points
none	0
scale	1
verrucous or hypertrophic	2

 

subscore for scale or hypertrophy =

= SUM(points for scale or hypertrophy in each anatomic location)

 

subscore for lesions on mucous membranes =

= (0 if absent, 1 if present)

 

subscore for recent hair loss

= (0 if absent, 1 if present)

 

Alopecia	Points
none	0
diffuse, noninflammatory	1
focal or patchy in one quadrant	2
focal or patchy in more than one quadrant	3

 

total activity score =

= (points for erythema) + (points for scale or hypertrophy) + (points for mucous membrane lesions) + (points for recent hair loss) + (points for alopecia)

 

Interpretation:

• minimum total activity score: 0

• maximum total activity score: 70

• The higher the score the greater the disease activity.