Systemic sarcoidosis may resolve within a few years or persist for many years. Certain clinical features may help identify a person who is likely to have an acute or chronic course.
Features of acute, self-limited disease:
(1) Stage 1 changes on the chest radiograph
(2) erythema nodosum
(3) anterior uveitis
(4) hypercalcemia
(5) palsy of the seventh cranial nerve (Bell's palsy)
Features associated with a chronic, refractory course:
(1) Stage 4 changes on the chest radiograph
(2) lupus pernio
(3) posterior uveitis
(4) pars planitis (pars plana = orbicularis ciliaris; pars planitis = intermediate uveitis)
(5) bone cysts
(6) renal stones (nephrolithiasis)
(7) cardiomyopathy (cardiac sarcoid)
(8) central nervous system disease with mass
(9) sinus involvement
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