Sciascia et al developed the Global Anti-Phospholipid Syndrome Score (GAPSS). The authors are from the King’s College London, Universita di Torino, and St. Thomas’ Hospital London.
Patient selection: SLE, other autoimmune disease
Parameters:
(1) hyperlipidemia
(2) arterial hypertension
(3) anticardiolipin antibodies IgG/IgM
(4) anti-beta2 glycoprotein I (GPI) antibodies IgG/IgM
(5) antibodies to solid-phase prothrombin and to phosphatidylserine-prothrombin complex (anti-PS/PT) IgG/IgM
(6) lupus anticoagulant
Parameter
Finding
Points
hyperlipidemia
absent
0
present
3
arterial hypertension
absent
0
present
1
anticardiolipin antibodies
absent
0
present
5
anti-beta2 GPI antibodies
absent
0
present
4
anti-PS/PT
absent
0
present
3
lupus anticoagulant
absent
0
present
4
total score =
= SUM(points for all 6 parameters)
Interpretation:
• minimum score: 0
• maximum score: 20
• A higher score was associated with thrombosis with or without pregnancy loss. Higher scores were also associated with recurrences.
• A lower score was associated with pregnancy loss alone.
Performance:
• A cutoff of >=10 was associated with an AUC of 0.74.
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