The Post-Thrombotic Syndrome tends to have nonspecific signs and symptoms, so that grading its severity may be difficult. Villalta et al developed a score for evaluating patients with the Post-Thrombotic Syndrome. The authors are from the Universities of Padua and Amsterdam.
Patients were evaluated 6 to 36 months after venography confirmed deep vein thrombosis in the lower extremity.
Clinical symptoms:
(1) pain
(2) cramps
(3) pruritis
(4) paresthesia
Clinical objective signs:
(1) pretibial edema
(2) induration of the skin
(3) hyperpigmentation
(4) new venous ectasia
(5) redness
NOTE: The use of signs and symptoms in the paper are reversed, probably as a result of the translation into English.
Severity |
Points |
none or minimal |
0 |
mild |
1 |
moderate |
2 |
severe |
3 |
subscore for clinical symptoms =
= SUM(points for clinical symptoms)
subscore for clinical signs =
= SUM(points for clinical signs)
total score =
= (clinical signs subscore) + (clinical symptoms subscore)
Interpretation:
• minimum scores: 0
• maximum clinical symptoms subscore: 12
• maximum clinical signs subscore: 15
• maximum total score: 27
Total Score |
Grade of PTS |
0 – 4 |
no or minimal |
5 – 14 |
mild to moderate |
>= 15 |
severe |
Performance:
• The kappa values for interobserver agreement for deriving scores was 0.77 to 0.80.
• The kappa value for assigning disease severity was 0.75 (95% CI 0.51 – 0.99).
Specialty: Hematology Oncology, Clinical Laboratory