Description

The Post-Thrombotic Syndrome tends to have nonspecific signs and symptoms, so that grading its severity may be difficult. Villalta et al developed a score for evaluating patients with the Post-Thrombotic Syndrome. The authors are from the Universities of Padua and Amsterdam.


 

Patients were evaluated 6 to 36 months after venography confirmed deep vein thrombosis in the lower extremity.

 

Clinical symptoms:

(1) pain

(2) cramps

(3) pruritis

(4) paresthesia

 

Clinical objective signs:

(1) pretibial edema

(2) induration of the skin

(3) hyperpigmentation

(4) new venous ectasia

(5) redness

 

NOTE: The use of signs and symptoms in the paper are reversed, probably as a result of the translation into English.

Severity

Points

none or minimal

0

mild

1

moderate

2

severe

3

 

subscore for clinical symptoms =

= SUM(points for clinical symptoms)

 

subscore for clinical signs =

= SUM(points for clinical signs)

 

total score =

= (clinical signs subscore) + (clinical symptoms subscore)

 

Interpretation:

• minimum scores: 0

• maximum clinical symptoms subscore: 12

• maximum clinical signs subscore: 15

• maximum total score: 27

 

Total Score

Grade of PTS

0 – 4

no or minimal

5 – 14

mild to moderate

>= 15

severe

 

Performance:

• The kappa values for interobserver agreement for deriving scores was 0.77 to 0.80.

• The kappa value for assigning disease severity was 0.75 (95% CI 0.51 – 0.99).

 


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