A number of qualitative disorders of the globin structure of hemoglobin can result in red blood cell sickling.
Hemoglobinopathies associated with sickling:
(1) hemoglobin SS (sickle cell disease)
(2) hemoglobin AS (sickle cell trait)
(3) hemoglobin SC
(4) hemoglobin S beta-thalassemia
(5) hemoglobin S with hereditary persistent of hemoglobin F
(6) hemoglobin SD
(7) hemoglobin SO-Arab
