(5) Reduce the splenic volume to less than 8 times normal (preferable less than 2 times).
Goals for a child with hepatomegaly:
(1) Reduce the liver volume to <= 1.5 times normal and maintain this size.
A significant reduction in organ size should be achieved over 5 years (50-60% reduction for spleen, 30-40% reduction for liver) with half of the reduction achieved in the first 2 years.
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