TNM Classification of Rindi et al for a Malignant Neuroendocrine Tumor Arising in the Pancreas

Description

Rindi et al proposed a TNM classification for a malignant neuroendocrine tumor arising in the pancreas. The authors are from multiple hospitals in Europe and North America who participated in the Frascati Consensus Conference in Rome.

Parameters:

(1) location of the tumor

(2) diameter in cm

(3) metastases to regional lymph nodes

(4) distant metastases

Location of the Tumor	Diameter in cm	T Code
cannot be assessed	NA	Tx
no evidence of a primary tumor	NA	T0
limited to the pancreas	< 2 cm	T1
limited to the pancreas	2 - 4 cm	T2
limited to the pancreas	> 4 cm	T3
invading duodenum or bile duct	NA	T3
invading stomach, spleen, colon and/or adrenal gland	NA	T4
invading wall of a major blood vessel (celiac axis, superior mesenteric artery)	NA	T4

If multiple primary tumors are present, then a suffix "m" is appended to the T code.

Regional Lymph Nodes	N Code
cannot be assessed	Nx
no metastases	N0
metastases present	N1

Distant Metastases	M Code
cannot be assessed	Mx
no distant metastases	M0
distant metastases present	M1

T Code	N Code	M Code	Stage
T1	N0	M0	I
T2	N0	M0	IIa
T3	N0	M0	IIb
T4	N0	M0	IIIa
NA	N1	M0	IIIb
NA	NA	M1	IV

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Description

Specialty

ICD-10