Pyruvate kinase deficiency results in a glycolytic defect in red blood cells. Certain conditions can trigger a hemolytic episode.
Hemolytic triggers:
(1) infection, including infection-related cold agglutinin disease
(2) stress
(3) pregnancy
(4) drugs (aspirin, antibiotics, etc)
Differential diagnosis:
(1) hemolytic transfusion reaction
A direct antiglobulin test may be helpful in triaging the patients.
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Specialty: Hematology Oncology
