Features of unexplained hematologic disorder of the elderly:
(1) older adult (typically >= 65 years of age)
(2) hematologic disorder not explained by comorbid condition (malnutrition, renal disease, etc)
(3) workup incomplete
Parameters:
(1) cytopenia
(2) clonal or molecular aberration
(3) cytogenetic abnormalities
|
Cytopenia
|
Molecular Aberration
|
Cytogenetic Abnormality
|
Diagnosis
|
|
present
|
absent
|
-/+
|
ICUS
|
|
present
|
present
|
negative
|
CCUS
|
|
absent
|
absent
|
-/+
|
IDUS
|
|
absent
|
present
|
+/-
|
CHIP
|
|
present
|
present
|
present
|
MDS
|
ICUS = idiopathic cytopenia of unknown significance
CCUS = clonal cytopenia of unknown significance
IDUS = idiopathic dysplasia of unknown significance
CHIP = clonal hematopoiesis of indeterminate potential
MDS = myelodysplastic syndrome
The trigger for a workup of ICUS and CCUS would be cytopenia. Recognition for IDUS and CHIP could be delayed.
