Narayanan et al used to the PaO2 to FIO2 ratio to evaluate neonates with the meconium aspiration syndrome (MAS). This can help to identify a patient who may require aggressive management. The authors are from the University College of Medical Sciences and Guru Tegh Bahadur Hospital in Delhi, India.
Patient selection: neonate with meconium aspiration syndrome (MAS)
A PaO2/FIO2 ratio < 200 at 6, 12 and/or 24 hours was associated with severe MS and mortality.
A SpO2/FIO2 ratio < 236.6 at 24 hours was also a good indicator of a poor outcome.
Performance:
• The sensitivity was 94% and specificity 97% for ratio < 200 at 24 hours. The area under the ROC curve was 0.95.
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