Hoff et al used a weight-based extended-interval dosing protocol for gentamicin in critically-ill neonates. A simple protocol can often perform adequately. The authors are from Children's Hospital and Clinics of Minnesota in Minneapolis.
Patient selection: neonate receiving intensive care
Targets: peak plasma gentamicin concentration of 7-10 mg/L with trough concentrations less than 2 mg/L
Parameters:
(1) body weight at birth in grams
(2) concurrent therapy with indomethacin
Basic dose: 4 mg per kg given intravenously
Patient Feature
Interval Between Doses
< 1,250 g at birth
every 48 hours
indomethacin therapy
every 48 hours
other
every 24 hours
Plasma trough and peak levels should be used to refine the drug regimen.
To read more or access our algorithms and calculators, please log in or register.
