Western blot analysis of insoluble tau proteins can identify bands associated with specific types of tauopathies.
Specimen: sarcosyl-insoluble proteins from brain biopsy
Band identification: mmunostaining with anti-tau antibodies
Bands on Western blot protein electropheresis
(1) 55 kilodaltons
(2) 64 kilodaltons
(3) 68 kilodaltons
|
55 kDa
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64 kDa
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68kDa
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Diagnosis
|
|
present
|
present
|
present
|
AD, FTDP-17 non exon 10 mutations
|
|
present
|
present
|
absent
|
Pick's disease
|
|
absent
|
present
|
present
|
PSP, CBD, FTDP-17 with exon 10 mutations
|
AD = Alzheimer's disease
PSP = progressive supranuclear palsy
CBD = corticobulbar degeneration
FTDP-17 = frontotemporal dementia and Parkinsonism linked to chromosome 17
