The World Health Organization (WHO) published criteria for acute and subacute toxic effects on the urinary tract following cancer therapy.
Measures
No Change (Grade 0)
(1) blood urea nitrogen or creatinine
<= 1.25 times the upper limit of reference range (ULN)
(2) proteinuria
"none" (see below)
(3) hematuria
none
where:
• A small amount of urine is usually present in the urine. According to Tietz (Clinical Guide to Laboratory Tests, Third Edition, 1995) this is 1-14 mg/dL (0.01 – 0.14 g/L).
Grade 1
Grade 2
Grade 3
Grade 4
blood urea nitrogen or creatinine
1.26 – 2.5 times ULN
2.6 – 5.0 times ULN
5.1 – 10.0 times ULN
> 10 times ULN
proteinuria
"< 3 g/L" (0.15 - 3 g/L)
3 – 10 g/L
> 10 g/L
nephrotic syndrome
hematuria
microscopic
gross
gross with clots
obstructive uropathy
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