The World Heath Organization (WHO) developed criteria for the diagnosis of mast cell leukemia.
Criteria for the diagnosis of mast cell leukemia:
(1) meets the criteria for systemic mastocytosis
(2) biopsy shows a diffuse infiltration by atypical, immature mast cells, usually showing an interstitial pattern
(3) bone marrow aspirate shows >= 20% mast cells
Percent Mast Cells in Peripheral Blood
Diagnosis
>= 10%
mast cell leukemia
< 10%
aleukemic mast cell leukemia
where:
• The percent bone marrow mast cell is one of the minor criteria for systemic mastocytosis.
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Specialty: Hematology Oncology, Clinical Laboratory
ICD-10: ,
